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An atomic structure of human γ-secretase
Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer’s disease (AD), with most AD-derived mutations mapping to the catalytic subunit presenilin 1 (PS1). Here we report an atomic structure of human γ-secretase at 3.4 Å resolution, determined by single-particle cryo-elec...
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| Veröffentlicht in: | Nature |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4568306/ https://ncbi.nlm.nih.gov/pubmed/26280335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14892 |
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