A Synthetic Antibody Fragment Targeting Nicastrin Affects Assembly and Trafficking of γ-Secretase

The γ-secretase complex, composed of presenilin, nicastrin (NCT), anterior pharynx-defective 1 (APH-1), and presenilin enhancer 2 (PEN-2), is assembled in a highly regulated manner and catalyzes the intramembranous proteolysis of many type I membrane proteins, including Notch and amyloid precursor p...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Zhang, Xulun, Hoey, Robert, Koide, Akiko, Dolios, Georgia, Paduch, Marcin, Nguyen, Phuong, Wu, Xianzhong, Li, Yueming, Wagner, Steven L., Wang, Rong, Koide, Shohei, Sisodia, Sangram S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263884/
https://ncbi.nlm.nih.gov/pubmed/25352592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.609636
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