Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components

γ-Secretase, which is responsible for the intramembranous cleavage of Alzheimer β-amyloid precursor protein and the signaling receptor Notch, is a multiprotein complex consisting of at least four components: presenilin (PS); nicastrin (Nct); APH-1 (anterior pharynx-defective-1); and presenilin enhan...

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Detalhes bibliográficos
Main Authors: Zhang, Yun-wu, Luo, Wen-jie, Wang, Hong, Lin, Ping, Vetrivel, Kulandaivelu S., Liao, Fang, Li, Feng, Wong, Philip C., Farquhar, Marilyn G., Thinakaran, Gopal, Xu, Huaxi
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201533/
https://ncbi.nlm.nih.gov/pubmed/15711015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M409467200
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