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Generating conformation-specific synthetic antibodies to trap proteins in selected functional states
A set of phage display sorting strategies and validation methodologies are presented that are capable of producing high performance synthetic antibodies (sABs) with customized properties. Exquisite control of antigen and conditions during the phage display selection process can yield sABs that: 1) r...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650108/ https://ncbi.nlm.nih.gov/pubmed/23280336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2012.12.010 |
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