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Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar K(D) of a single-domain antibody with a flat paratope
A major architectural class in engineered binding proteins (“antibody mimics”) involves the presentation of recognition loops off a single-domain scaffold. This class of binding proteins, both natural and synthetic, has a strong tendency to bind a preformed cleft using a convex binding interface (pa...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2148503/ https://ncbi.nlm.nih.gov/pubmed/17888451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.08.027 |
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