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High-affinity single-domain binding proteins with a binary-code interface

High degrees of sequence and conformation complexity found in natural protein interaction interfaces are generally considered essential for achieving tight and specific interactions. However, it has been demonstrated that specific antibodies can be built by using an interface with a binary code cons...

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Autori principali: Koide, Akiko, Gilbreth, Ryan N., Esaki, Kaori, Tereshko, Valentina, Koide, Shohei
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871837/
https://ncbi.nlm.nih.gov/pubmed/17420456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700149104
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