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High-affinity single-domain binding proteins with a binary-code interface

High degrees of sequence and conformation complexity found in natural protein interaction interfaces are generally considered essential for achieving tight and specific interactions. However, it has been demonstrated that specific antibodies can be built by using an interface with a binary code cons...

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Autors principals: Koide, Akiko, Gilbreth, Ryan N., Esaki, Kaori, Tereshko, Valentina, Koide, Shohei
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1871837/
https://ncbi.nlm.nih.gov/pubmed/17420456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700149104
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