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Design of protein function leaps by directed domain interface evolution
Most natural proteins performing sophisticated tasks contain multiple domains where an active site is located at the domain interface. Comparative structural analyses suggest that major leaps in protein function occur through gene recombination events that connect two or more protein domains to gene...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373342/ https://ncbi.nlm.nih.gov/pubmed/18445649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801097105 |
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