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Design of protein function leaps by directed domain interface evolution

Most natural proteins performing sophisticated tasks contain multiple domains where an active site is located at the domain interface. Comparative structural analyses suggest that major leaps in protein function occur through gene recombination events that connect two or more protein domains to gene...

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Detalles Bibliográficos
Main Authors: Huang, Jin, Koide, Akiko, Makabe, Koki, Koide, Shohei
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373342/
https://ncbi.nlm.nih.gov/pubmed/18445649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801097105
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