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Molecular Mechanism of Thioflavin-T Binding to the Surface of β-Rich Peptide Self-Assemblies
A number of small organic molecules have been developed that bind to amyloid fibrils, a subset of which also inhibit fibrillization. Among these, the benzothiol dye, Thioflavin-T (ThT), has for decades been used in the diagnosis of protein-misfolding diseases and also in kinetic studies of self-asse...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664162/ https://ncbi.nlm.nih.gov/pubmed/19038267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.11.006 |
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