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A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein-Protein Interfaces
Recent studies have shown that highly simplified interaction surfaces consisting of combinations of just two amino acids, Tyr and Ser, exhibit high affinity and specificity. The high functional levels of such minimalist interfaces might thus indicate small contributions of greater amino acid diversi...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2582520/ https://ncbi.nlm.nih.gov/pubmed/18602117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.06.014 |
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