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The Importance of Being Tyrosine: Lessons in Molecular Recognition from Minimalist Synthetic Binding Proteins

Combinatorial libraries built with severely restricted chemical diversity have yielded highly functional synthetic binding proteins. Structural analyses of these minimalist binding sites have revealed the dominant role of large tyrosine residues for mediating molecular contacts and of small serine/g...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Koide, Shohei, Sidhu, Sachdev S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829252/
https://ncbi.nlm.nih.gov/pubmed/19298050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb800314v
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