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Different cofactor activities in γ-secretase assembly: evidence for a nicastrin–Aph-1 subcomplex

The γ-secretase complex is required for intramembrane cleavage of several integral membrane proteins, including the Notch receptor, where it generates an active signaling fragment. Four putative γ-secretase components have been identified—presenilin (Psn), nicastrin (Nct), Aph-1, and Pen-2. Here, we...

詳細記述

保存先:
書誌詳細
主要な著者: Hu, Yue, Fortini, Mark E.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199374/
https://ncbi.nlm.nih.gov/pubmed/12771124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200304014
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