Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

Neuregulin 1 (NRG1) and the γ-secretase subunit APH1B have been previously implicated as genetic risk factors for schizophrenia and schizophrenia relevant deficits have been observed in rodent models with loss of function mutations in either gene. Here we show that the Aph1b-γ-secretase is selective...

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Detalhes bibliográficos
Main Authors: Fazzari, Pietro, Snellinx, An, Sabanov, Victor, Ahmed, Tariq, Serneels, Lutgarde, Gartner, Annette, Shariati, S Ali M, Balschun, Detlef, De Strooper, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073283/
https://ncbi.nlm.nih.gov/pubmed/24891237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02196
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