Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

BACE1 is the major drug target for Alzheimer's disease, but we know surprisingly little about its normal function in the CNS. Here, we show that this protease is critically involved in semaphorin 3A (Sema3A)-mediated axonal guidance processes in thalamic and hippocampal neurons. An active membr...

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Pubblicato in:Cell Rep
Autori principali: Barão, Soraia, Gärtner, Annette, Leyva-Díaz, Eduardo, Demyanenko, Galina, Munck, Sebastian, Vanhoutvin, Tine, Zhou, Lujia, Schachner, Melitta, López-Bendito, Guillermina, Maness, Patricia F., De Strooper, Bart
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820248/
https://ncbi.nlm.nih.gov/pubmed/26299962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.059
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