Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

BACE1 is the major drug target for Alzheimer's disease, but we know surprisingly little about its normal function in the CNS. Here, we show that this protease is critically involved in semaphorin 3A (Sema3A)-mediated axonal guidance processes in thalamic and hippocampal neurons. An active membr...

詳細記述

保存先:
書誌詳細
出版年:Cell Rep
主要な著者: Barão, Soraia, Gärtner, Annette, Leyva-Díaz, Eduardo, Demyanenko, Galina, Munck, Sebastian, Vanhoutvin, Tine, Zhou, Lujia, Schachner, Melitta, López-Bendito, Guillermina, Maness, Patricia F., De Strooper, Bart
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4820248/
https://ncbi.nlm.nih.gov/pubmed/26299962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.059
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