γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease

The γ-secretase complex plays a role in Alzheimer’s disease (AD) and cancer progression. The development of clinical useful inhibitors, however, is complicated by the role of the γ-secretase complex in regulated intramembrane proteolysis of Notch and other essential proteins. Different γ-secretase c...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Serneels, Lutgarde, Van Biervliet, Jérôme, Craessaerts, Katleen, Dejaegere, Tim, Horré, Katrien, Van Houtvin, Tine, Esselmann, Hermann, Paul, Sabine, Schäfer, Martin K., Berezovska, Oksana, Hyman, Bradley T., Sprangers, Ben, Sciot, Raf, Moons, Lieve, Jucker, Mathias, Yang, Zhixiang, May, Patrick C., Karran, Eric, Wiltfang, Jens, D’Hooge, Rudi, De Strooper, Bart
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740474/
https://ncbi.nlm.nih.gov/pubmed/19299585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1171176
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