γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease

The γ-secretase complex plays a role in Alzheimer’s disease (AD) and cancer progression. The development of clinical useful inhibitors, however, is complicated by the role of the γ-secretase complex in regulated intramembrane proteolysis of Notch and other essential proteins. Different γ-secretase c...

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Hlavní autoři: Serneels, Lutgarde, Van Biervliet, Jérôme, Craessaerts, Katleen, Dejaegere, Tim, Horré, Katrien, Van Houtvin, Tine, Esselmann, Hermann, Paul, Sabine, Schäfer, Martin K., Berezovska, Oksana, Hyman, Bradley T., Sprangers, Ben, Sciot, Raf, Moons, Lieve, Jucker, Mathias, Yang, Zhixiang, May, Patrick C., Karran, Eric, Wiltfang, Jens, D’Hooge, Rudi, De Strooper, Bart
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740474/
https://ncbi.nlm.nih.gov/pubmed/19299585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1171176
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