γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease

The γ-secretase complex plays a role in Alzheimer’s disease (AD) and cancer progression. The development of clinical useful inhibitors, however, is complicated by the role of the γ-secretase complex in regulated intramembrane proteolysis of Notch and other essential proteins. Different γ-secretase c...

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Bibliografiska uppgifter
Huvudupphovsmän: Serneels, Lutgarde, Van Biervliet, Jérôme, Craessaerts, Katleen, Dejaegere, Tim, Horré, Katrien, Van Houtvin, Tine, Esselmann, Hermann, Paul, Sabine, Schäfer, Martin K., Berezovska, Oksana, Hyman, Bradley T., Sprangers, Ben, Sciot, Raf, Moons, Lieve, Jucker, Mathias, Yang, Zhixiang, May, Patrick C., Karran, Eric, Wiltfang, Jens, D’Hooge, Rudi, De Strooper, Bart
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740474/
https://ncbi.nlm.nih.gov/pubmed/19299585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1171176
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