Inhibition of β-Secretase in Vivo via Antibody Binding to Unique Loops (D and F) of BACE1

Por Zhou, Lujia, Chávez-Gutiérrez, Lucia, Bockstael, Katrijn, Sannerud, Ragna, Annaert, Wim, May, Patrick C., Karran, Eric, De Strooper, Bart
Publicado em 2011

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage

Por Portelius, Erik, Dean, Robert A, Andreasson, Ulf, Mattsson, Niklas, Westerlund, Anni, Olsson, Maria, Demattos, Ronald Bradley, Racke, Margaret M, Zetterberg, Henrik, May, Patrick C, Blennow, Kaj
Publicado no Alzheimers Res Ther (2014)

A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans

Por Hölttä, Mikko, Dean, Robert A., Siemers, Eric, Mawuenyega, Kwasi G., Sigurdson, Wendy, May, Patrick C., Holtzman, David M., Portelius, Erik, Zetterberg, Henrik, Bateman, Randall J., Blennow, Kaj, Gobom, Johan
Publicado no Alzheimers Res Ther (2016)

A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system

Por Bateman, Randall J., Siemers, Eric R., Mawuenyega, Kwasi G., Wen, Guolin, Browning, Karen R., Sigurdson, Wendy C., Yarasheski, Kevin E., Friedrich, Stuart W., DeMattos, Ronald B., May, Patrick C., Paul, Steven M., Holtzman, David M.
Publicado em 2009

In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

Por Cirrito, John R., May, Patrick C., O'Dell, Mark A., Taylor, Jennie W., Parsadanian, Maia, Cramer, Jeffrey W., Audia, James E., Nissen, Jeffrey S., Bales, Kelly R., Paul, Steven M., DeMattos, Ronald B., Holtzman, David M.
Publicado no J Neurosci (2003)

Aβ(1-15/16) as a marker for γ-secretase inhibition in Alzheimer’s disease

Por Portelius, Erik, Zetterberg, Henrik, Dean, Robert A., Marcil, Alexandre, Bourgeois, Philippe, Nutu, Magdalena, Andreasson, Ulf, Siemers, Eric, Mawuenyega, Kwasi G., Sigurdson, Wendy C., May, Patrick C., Paul, Steven M., Holtzman, David M., Blennow, Kaj, Bateman, Randall J.
Publicado em 2012

Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposit...

Por Racke, Margaret M., Boone, Laura I., Hepburn, Deena L., Parsadainian, Maia, Bryan, Matthew T., Ness, Daniel K., Piroozi, Kathy S., Jordan, William H., Brown, Donna D., Hoffman, Wherly P., Holtzman, David M., Bales, Kelly R., Gitter, Bruce D., May, Patrick C., Paul, Steven M., DeMattos, Ronald B.
Publicado no J Neurosci (2005)

γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease

Por Serneels, Lutgarde, Van Biervliet, Jérôme, Craessaerts, Katleen, Dejaegere, Tim, Horré, Katrien, Van Houtvin, Tine, Esselmann, Hermann, Paul, Sabine, Schäfer, Martin K., Berezovska, Oksana, Hyman, Bradley T., Sprangers, Ben, Sciot, Raf, Moons, Lieve, Jucker, Mathias, Yang, Zhixiang, May, Patrick C., Karran, Eric, Wiltfang, Jens, D’Hooge, Rudi, De Strooper, Bart
Publicado em 2009

Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor

Por May, Patrick C., Dean, Robert A., Lowe, Stephen L., Martenyi, Ferenc, Sheehan, Scott M., Boggs, Leonard N., Monk, Scott A., Mathes, Brian M., Mergott, Dustin J., Watson, Brian M., Stout, Stephanie L., Timm, David E., Smith LaBell, Elizabeth, Gonzales, Celedon R., Nakano, Masako, Jhee, Stanford S., Yen, Mark, Ereshefsky, Larry, Lindstrom, Terry D., Calligaro, David O., Cocke, Patrick J., Greg Hall, D., Friedrich, Stuart, Citron, Martin, Audia, James E.
Publicado no J Neurosci (2011)

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans

Por May, Patrick C., Willis, Brian A., Lowe, Stephen L., Dean, Robert A., Monk, Scott A., Cocke, Patrick J., Audia, James E., Boggs, Leonard N., Borders, Anthony R., Brier, Richard A., Calligaro, David O., Day, Theresa A., Ereshefsky, Larry, Erickson, Jon A., Gevorkyan, Hykop, Gonzales, Celedon R., James, Douglas E., Jhee, Stanford S., Komjathy, Steven F., Li, Linglin, Lindstrom, Terry D., Mathes, Brian M., Martényi, Ferenc, Sheehan, Scott M., Stout, Stephanie L., Timm, David E., Vaught, Grant M., Watson, Brian M., Winneroski, Leonard L., Yang, Zhixiang, Mergott, Dustin J.
Publicado no J Neurosci (2015)