Alzheimer's Research U.K.: Defeating Dementia Through Research

por Karran, Eric
Publicado 2012

A Critique of the Drug Discovery and Phase 3 Clinical Programs Targeting the Amyloid Hypothesis for Alzheimer Disease

por Karran, Eric, Hardy, John
Publicado 2014

Basic to translational research in dementia: meeting report from the Alzheimer’s Research UK Conference 2014

por Sancho, Rosa M, Ridley, Simon H, Phipps, Laura E, Karran, Eric
Publicado 2014

Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface.

por Balyasnikova, Irina V, Karran, Eric H, Albrecht, Ronald F, Danilov, Sergei M
Publicado 2002

Report from the Alzheimer’s Research UK Conference 2015

por Sancho, Rosa M., Cox, Carla J., Ridley, Simon H., Phipps, Laura E., Karran, Eric
Publicado en Alzheimers Res Ther (2015)

Inhibition of β-Secretase in Vivo via Antibody Binding to Unique Loops (D and F) of BACE1

por Zhou, Lujia, Chávez-Gutiérrez, Lucia, Bockstael, Katrijn, Sannerud, Ragna, Annaert, Wim, May, Patrick C., Karran, Eric, De Strooper, Bart
Publicado 2011

MEK1/2 activity modulates TREM2 cell surface recruitment

por Schapansky, Jason, Grinberg, Yelena Y., Osiecki, David M., Freeman, Emily A., Walker, Stephen G., Karran, Eric, Gopalakrishnan, Sujatha M., Talanian, Robert V.
Publicado en J Biol Chem (2020)

Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model

por Duan, Lishu, Hu, Mufeng, Tamm, Joseph A., Grinberg, Yelena Y., Shen, Fang, Chai, Yating, Xi, Hualin, Gibilisco, Lauren, Ravikumar, Brinda, Gautam, Vivek, Karran, Eric, Townsend, Matthew, Talanian, Robert V.
Publicado en Sci Rep (2021)

An Unbiased Approach to Identifying Tau Kinases That Phosphorylate Tau at Sites Associated with Alzheimer Disease

por Cavallini, Annalisa, Brewerton, Suzanne, Bell, Amanda, Sargent, Samantha, Glover, Sarah, Hardy, Clare, Moore, Roger, Calley, John, Ramachandran, Devaki, Poidinger, Michael, Karran, Eric, Davies, Peter, Hutton, Michael, Szekeres, Philip, Bose, Suchira
Publicado 2013

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses

por Redondo-Castro, Elena, Faust, Dorte, Fox, Simon, Baldwin, Alex G., Osborne, Simon, Haley, Michael J., Karran, Eric, Nuthall, Hugh, Atkinson, Peter J., Dawson, Lee A., Routledge, Carol, Allan, Stuart M., Freeman, Sally, Brownlees, Janet, Brough, David
Publicado en Sci Rep (2018)

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

por Chávez-Gutiérrez, Lucía, Bammens, Leen, Benilova, Iryna, Vandersteen, Annelies, Benurwar, Manasi, Borgers, Marianne, Lismont, Sam, Zhou, Lujia, Van Cleynenbreugel, Simon, Esselmann, Hermann, Wiltfang, Jens, Serneels, Lutgarde, Karran, Eric, Gijsen, Harrie, Schymkowitz, Joost, Rousseau, Frederic, Broersen, Kerensa, De Strooper, Bart
Publicado 2012

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

por Frigerio, Carlo Sala, Wolfs, Leen, Fattorelli, Nicola, Thrupp, Nicola, Voytyuk, Iryna, Schmidt, Inga, Mancuso, Renzo, Chen, Wei-Ting, Woodbury, Maya E., Srivastava, Gyan, Möller, Thomas, Hudry, Eloise, Das, Sudeshna, Saido, Takaomi, Karran, Eric, Hyman, Bradley, Perry, V. Hugh, Fiers, Mark, De Strooper, Bart
Publicado en Cell Rep (2019)

Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration

por Obst, Juliane, Simon, Emilie, Martin-Estebane, Maria, Pipi, Elena, Barkwill, Liana M., Gonzalez-Rivera, Ivette, Buchanan, Fergus, Prescott, Alan R., Faust, Dorte, Fox, Simon, Brownlees, Janet, Taylor, Debra, Perry, V. Hugh, Nuthall, Hugh, Atkinson, Peter J., Karran, Eric, Routledge, Carol, Gomez-Nicola, Diego
Publicado en Front Immunol (2020)

γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease

por Serneels, Lutgarde, Van Biervliet, Jérôme, Craessaerts, Katleen, Dejaegere, Tim, Horré, Katrien, Van Houtvin, Tine, Esselmann, Hermann, Paul, Sabine, Schäfer, Martin K., Berezovska, Oksana, Hyman, Bradley T., Sprangers, Ben, Sciot, Raf, Moons, Lieve, Jucker, Mathias, Yang, Zhixiang, May, Patrick C., Karran, Eric, Wiltfang, Jens, D’Hooge, Rudi, De Strooper, Bart
Publicado 2009

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

por Siddiqi, Farah H., Menzies, Fiona M., Lopez, Ana, Stamatakou, Eleanna, Karabiyik, Cansu, Ureshino, Rodrigo, Ricketts, Thomas, Jimenez-Sanchez, Maria, Esteban, Miguel Angel, Lai, Liangxue, Tortorella, Micky D., Luo, Zhiwei, Liu, Hao, Metzakopian, Emmanouil, Fernandes, Hugo J. R., Bassett, Andrew, Karran, Eric, Miller, Bruce L., Fleming, Angeleen, Rubinsztein, David C.
Publicado en Nat Commun (2019)

Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

por Siddiqi, Farah H., Menzies, Fiona M., Lopez, Ana, Stamatakou, Eleanna, Karabiyik, Cansu, Ureshino, Rodrigo, Ricketts, Thomas, Jimenez-Sanchez, Maria, Esteban, Miguel Angel, Lai, Liangxue, Tortorella, Micky D., Luo, Zhiwei, Liu, Hao, Metzakopian, Emmanouil, Fernandes, Hugo J. R., Bassett, Andrew, Karran, Eric, Miller, Bruce L., Fleming, Angeleen, Rubinsztein, David C.
Publicado en Nat Commun (2019)