Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

Neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease and Huntington’s disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have soug...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Siddiqi, Farah H., Menzies, Fiona M., Lopez, Ana, Stamatakou, Eleanna, Karabiyik, Cansu, Ureshino, Rodrigo, Ricketts, Thomas, Jimenez-Sanchez, Maria, Esteban, Miguel Angel, Lai, Liangxue, Tortorella, Micky D., Luo, Zhiwei, Liu, Hao, Metzakopian, Emmanouil, Fernandes, Hugo J. R., Bassett, Andrew, Karran, Eric, Miller, Bruce L., Fleming, Angeleen, Rubinsztein, David C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6472390/
https://ncbi.nlm.nih.gov/pubmed/31000720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09494-2
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky