A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans

BACKGROUND: In Alzheimer’s disease, beta-amyloid peptides in the brain aggregate into toxic oligomers and plaques, a process which is associated with neuronal degeneration, memory loss, and cognitive decline. One therapeutic strategy is to decrease the production of potentially toxic beta-amyloid sp...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Alzheimers Res Ther
Prif Awduron: Hölttä, Mikko, Dean, Robert A., Siemers, Eric, Mawuenyega, Kwasi G., Sigurdson, Wendy, May, Patrick C., Holtzman, David M., Portelius, Erik, Zetterberg, Henrik, Bateman, Randall J., Blennow, Kaj, Gobom, Johan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780148/
https://ncbi.nlm.nih.gov/pubmed/26948580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-016-0178-x
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