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A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans
BACKGROUND: In Alzheimer’s disease, beta-amyloid peptides in the brain aggregate into toxic oligomers and plaques, a process which is associated with neuronal degeneration, memory loss, and cognitive decline. One therapeutic strategy is to decrease the production of potentially toxic beta-amyloid sp...
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| Veröffentlicht in: | Alzheimers Res Ther |
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| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4780148/ https://ncbi.nlm.nih.gov/pubmed/26948580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-016-0178-x |
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