Neurobiology of Alzheimer’s Disease: Integrated Molecular, Physiological, Anatomical, Biomarker, and Cognitive Dimensions

od Raskin, Joel, Cummings, Jeffrey, Hardy, John, Schuh, Kory, Dean, Robert A.
izdano v Curr Alzheimer Res (2015)

A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease

od Portelius, Erik, Dean, Robert A, Gustavsson, Mikael K, Andreasson, Ulf, Zetterberg, Henrik, Siemers, Eric, Blennow, Kaj
Izdano 2010

Quantile regression to characterize solanezumab effects in Alzheimer's disease trials

od Chen, Yun-Fei, Ma, Xiwen, Sundell, Karen, Alaka, Karla, Schuh, Kory, Raskin, Joel, Dean, Robert A.
izdano v Alzheimers Dement (N Y) (2016)

Florbetapir positron emission tomography and cerebrospinal fluid biomarkers

od Hake, Ann, Trzepacz, Paula T., Wang, Shufang, Yu, Peng, Case, Michael, Hochstetler, Helen, Witte, Michael M., Degenhardt, Elisabeth K., Dean, Robert A.
izdano v Alzheimers Dement (2015)

A digital enzyme-linked immunosorbent assay for ultrasensitive measurement of amyloid-β 1–42 peptide in human plasma with utility for studies of Alzheimer’s disease therapeutics...

od Song, Linan, Lachno, D. Richard, Hanlon, David, Shepro, Adam, Jeromin, Andreas, Gemani, Dipika, Talbot, Jayne A., Racke, Margaret M., Dage, Jeffrey L., Dean, Robert A.
izdano v Alzheimers Res Ther (2016)

β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage

od Portelius, Erik, Dean, Robert A, Andreasson, Ulf, Mattsson, Niklas, Westerlund, Anni, Olsson, Maria, Demattos, Ronald Bradley, Racke, Margaret M, Zetterberg, Henrik, May, Patrick C, Blennow, Kaj
izdano v Alzheimers Res Ther (2014)

An Enzyme-Generated Fragment of Tau Measured in Serum Shows an Inverse Correlation to Cognitive Function

od Henriksen, Kim, Wang, Yaguo, Sørensen, Mette G., Barascuk, Natasha, Suhy, Joyce, Pedersen, Jan T., Duffin, Kevin L., Dean, Robert A., Pajak, Monika, Christiansen, Claus, Zheng, Qinlong, Karsdal, Morten A.
Izdano 2013

A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans

od Hölttä, Mikko, Dean, Robert A., Siemers, Eric, Mawuenyega, Kwasi G., Sigurdson, Wendy, May, Patrick C., Holtzman, David M., Portelius, Erik, Zetterberg, Henrik, Bateman, Randall J., Blennow, Kaj, Gobom, Johan
izdano v Alzheimers Res Ther (2016)

Central pharmacodynamic activity of solanezumab in mild Alzheimer's disease dementia

od Willis, Brian A., Sundell, Karen, Lachno, D. Richard, Ferguson-Sells, Lisa R., Case, Michael G., Holdridge, Karen, DeMattos, Ronald B., Raskin, Joel, Siemers, Eric R., Dean, Robert A.
izdano v Alzheimers Dement (N Y) (2018)

Revolutionizing Alzheimer's disease and clinical trials through biomarkers

od Mattsson, Niklas, Carrillo, Maria C., Dean, Robert A., Devous, Michael D., Nikolcheva, Tania, Pesini, Pedro, Salter, Hugh, Potter, William Z., Sperling, Reisa S., Bateman, Randall J., Bain, Lisa J., Liu, Enchi
izdano v Alzheimers Dement (Amst) (2015)

Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI

od Shaw, Leslie M., Vanderstichele, Hugo, Knapik-Czajka, Malgorzata, Figurski, Michal, Coart, Els, Blennow, Kaj, Soares, Holly, Simon, Adam J., Lewczuk, Piotr, Dean, Robert A., Siemers, Eric, Potter, William, Lee, Virginia M.-Y., Trojanowski, John Q.
Izdano 2011

Phase II safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer's disease

od Fleisher, Adam S., Raman, Rema, Siemers, Eric R., Becerra, Lida, Clark, Christopher M., Dean, Robert A, Farlow, Martin R., Galvin, James E., Peskind, Elaine R., Quinn, Joseph F., Sherzai, Abdullah, Sowell, B. Brooke, Aisen, Paul S., Thal, Leon J.
Izdano 2008

Aβ(1-15/16) as a marker for γ-secretase inhibition in Alzheimer’s disease

od Portelius, Erik, Zetterberg, Henrik, Dean, Robert A., Marcil, Alexandre, Bourgeois, Philippe, Nutu, Magdalena, Andreasson, Ulf, Siemers, Eric, Mawuenyega, Kwasi G., Sigurdson, Wendy C., May, Patrick C., Paul, Steven M., Holtzman, David M., Blennow, Kaj, Bateman, Randall J.
Izdano 2012

Derivation of cutoffs for the Elecsys(®) amyloid β (1–42) assay in Alzheimer's disease

od Shaw, Leslie M., Waligorska, Teresa, Fields, Leona, Korecka, Magdalena, Figurski, Michal, Trojanowski, John Q., Eichenlaub, Udo, Wahl, Simone, Quan, Marian, Pontecorvo, Michael J., Lachno, D. Richard, Talbot, Jayne A., Andersen, Scott W., Siemers, Eric R., Dean, Robert A.
izdano v Alzheimers Dement (Amst) (2018)

Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease

od Soares, Holly D., Potter, William Z., Pickering, Eve, Kuhn, Max, Immermann, Frederick W., Shera, David M, Ferm, Mats, Dean, Robert A., Simon, Adam J., Swenson, Frank, Siuciak, Judith A., Kaplow, June, Thambisetty, Madhav, Zagouras, Panayiotis, Koroshetz, Walter J., Wan, Hong I., Trojanowski, John Q., Shaw, Leslie M.
Izdano 2012

The Alzheimer’s Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans

od Kang, Ju-Hee, Korecka, Magdalena, Figurski, Michal J., Toledo, Jon B., Blennow, Kaj, Zetterberg, Henrik, Waligorska, Teresa, Brylska, Magdalena, Fields, Leona, Shah, Nirali, Soares, Holly, Dean, Robert A., Vanderstichele, Hugo, Petersen, Ronald C., Aisen, Paul S., Saykin, Andrew J., Weiner, Michael W., Trojanowski, John Q., Shaw, Leslie M.
izdano v Alzheimers Dement (2015)

An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter

od Lucey, Brendan P., Gonzales, Celedon, Das, Ujjwas, Li, Jinhe, Siemers, Eric R., Slemmon, J. Randall, Bateman, Randall J., Huang, Yafei, Fox, Gerard B., Claassen, Jurgen A.H.R., Slats, Diane, Verbeek, Marcel M., Tong, Gary, Soares, Holly, Savage, Mary J., Kennedy, Matthew, Forman, Mark, Sjögren, Magnus, Margolin, Richard, Chen, Xia, Farlow, Martin R., Dean, Robert A., Waring, Jeffrey F.
izdano v Alzheimers Res Ther (2015)

Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor

od May, Patrick C., Dean, Robert A., Lowe, Stephen L., Martenyi, Ferenc, Sheehan, Scott M., Boggs, Leonard N., Monk, Scott A., Mathes, Brian M., Mergott, Dustin J., Watson, Brian M., Stout, Stephanie L., Timm, David E., Smith LaBell, Elizabeth, Gonzales, Celedon R., Nakano, Masako, Jhee, Stanford S., Yen, Mark, Ereshefsky, Larry, Lindstrom, Terry D., Calligaro, David O., Cocke, Patrick J., Greg Hall, D., Friedrich, Stuart, Citron, Martin, Audia, James E.
izdano v J Neurosci (2011)

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans

od May, Patrick C., Willis, Brian A., Lowe, Stephen L., Dean, Robert A., Monk, Scott A., Cocke, Patrick J., Audia, James E., Boggs, Leonard N., Borders, Anthony R., Brier, Richard A., Calligaro, David O., Day, Theresa A., Ereshefsky, Larry, Erickson, Jon A., Gevorkyan, Hykop, Gonzales, Celedon R., James, Douglas E., Jhee, Stanford S., Komjathy, Steven F., Li, Linglin, Lindstrom, Terry D., Mathes, Brian M., Martényi, Ferenc, Sheehan, Scott M., Stout, Stephanie L., Timm, David E., Vaught, Grant M., Watson, Brian M., Winneroski, Leonard L., Yang, Zhixiang, Mergott, Dustin J.
izdano v J Neurosci (2015)