An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter

INTRODUCTION: Amyloid-β (Aβ) has been investigated as a diagnostic biomarker and therapeutic drug target. Recent studies found that cerebrospinal fluid (CSF) Aβ fluctuates over time, including as a diurnal pattern, and increases in absolute concentration with serial collection. It is currently unkno...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Lucey, Brendan P., Gonzales, Celedon, Das, Ujjwas, Li, Jinhe, Siemers, Eric R., Slemmon, J. Randall, Bateman, Randall J., Huang, Yafei, Fox, Gerard B., Claassen, Jurgen A.H.R., Slats, Diane, Verbeek, Marcel M., Tong, Gary, Soares, Holly, Savage, Mary J., Kennedy, Matthew, Forman, Mark, Sjögren, Magnus, Margolin, Richard, Chen, Xia, Farlow, Martin R., Dean, Robert A., Waring, Jeffrey F.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518529/
https://ncbi.nlm.nih.gov/pubmed/26225140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-015-0136-z
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