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A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease
INTRODUCTION: LY450139 (semagacestat) inhibits γ-secretase, a key enzyme for generation of amyloid β (Aβ), the peptide deposited in plaques in Alzheimer disease (AD). Previous data have shown that LY450139 lowers plasma Aβ, but has no clear effect on Aβ1-40 or Aβ1-42 levels in cerebrospinal fluid (C...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2876785/ https://ncbi.nlm.nih.gov/pubmed/20350302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt30 |
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