A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease

INTRODUCTION: LY450139 (semagacestat) inhibits γ-secretase, a key enzyme for generation of amyloid β (Aβ), the peptide deposited in plaques in Alzheimer disease (AD). Previous data have shown that LY450139 lowers plasma Aβ, but has no clear effect on Aβ1-40 or Aβ1-42 levels in cerebrospinal fluid (C...

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Autores principales: Portelius, Erik, Dean, Robert A, Gustavsson, Mikael K, Andreasson, Ulf, Zetterberg, Henrik, Siemers, Eric, Blennow, Kaj
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876785/
https://ncbi.nlm.nih.gov/pubmed/20350302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt30
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