Effects of γ-Secretase Inhibition on the Amyloid β Isoform Pattern in a Mouse Model of Alzheimer's Disease

BACKGROUND: Accumulation of amyloid β (Aβ) in the brain is believed to represent one of the earliest events in the Alzheimer disease process. Aβ is generated from amyloid precursor protein after sequential cleavage by β- and γ-secretase. Alternatively, α-secretase cleaves within the Aβ sequence, thu...

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Hauptverfasser: Portelius, Erik, Zhang, Bin, Gustavsson, Mikael K., Brinkmalm, Gunnar, Westman-Brinkmalm, Ann, Zetterberg, Henrik, Lee, Virginia M.-Y., Trojanowski, John Q., Blennow, Kaj
Format: Artigo
Sprache:Inglês
Veröffentlicht: S. Karger AG 2010
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837891/
https://ncbi.nlm.nih.gov/pubmed/19955704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000264639
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