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Effects of γ-Secretase Inhibition on the Amyloid β Isoform Pattern in a Mouse Model of Alzheimer's Disease
BACKGROUND: Accumulation of amyloid β (Aβ) in the brain is believed to represent one of the earliest events in the Alzheimer disease process. Aβ is generated from amyloid precursor protein after sequential cleavage by β- and γ-secretase. Alternatively, α-secretase cleaves within the Aβ sequence, thu...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
S. Karger AG
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2837891/ https://ncbi.nlm.nih.gov/pubmed/19955704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000264639 |
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