Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid β-peptides in human cerebrospinal fluid

The proteolytic processing of human amyloid precursor protein (APP) into shorter aggregating amyloid β (Aβ)-peptides, e.g., Aβ1-42, is considered a critical step in the pathogenesis of Alzheimer’s disease (AD). Although APP is a well-known membrane glycoprotein carrying both N- and O-glycans, nothin...

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Main Authors: Halim, Adnan, Brinkmalm, Gunnar, Rüetschi, Ulla, Westman-Brinkmalm, Ann, Portelius, Erik, Zetterberg, Henrik, Blennow, Kaj, Larson, Göran, Nilsson, Jonas
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141957/
https://ncbi.nlm.nih.gov/pubmed/21712440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102664108
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