Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease

Pyroglutamate-modified Aβ peptides at amino acid position three (Aβ(pE3–42)) are gaining considerable attention as potential key players in the pathogenesis of Alzheimer disease (AD). Aβ(pE3–42) is abundant in AD brain and has a high aggregation propensity, stability and cellular toxicity. The aim o...

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Главные авторы: Wittnam, Jessica L., Portelius, Erik, Zetterberg, Henrik, Gustavsson, Mikael K., Schilling, Stephan, Koch, Birgit, Demuth, Hans-Ulrich, Blennow, Kaj, Wirths, Oliver, Bayer, Thomas A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Molecular Bases of Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318696/
https://ncbi.nlm.nih.gov/pubmed/22267726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308601
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