Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease

Pyroglutamate-modified Aβ peptides at amino acid position three (Aβ(pE3–42)) are gaining considerable attention as potential key players in the pathogenesis of Alzheimer disease (AD). Aβ(pE3–42) is abundant in AD brain and has a high aggregation propensity, stability and cellular toxicity. The aim o...

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Hlavní autoři: Wittnam, Jessica L., Portelius, Erik, Zetterberg, Henrik, Gustavsson, Mikael K., Schilling, Stephan, Koch, Birgit, Demuth, Hans-Ulrich, Blennow, Kaj, Wirths, Oliver, Bayer, Thomas A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318696/
https://ncbi.nlm.nih.gov/pubmed/22267726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308601
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