Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease

Pyroglutamate-modified Aβ peptides at amino acid position three (Aβ(pE3–42)) are gaining considerable attention as potential key players in the pathogenesis of Alzheimer disease (AD). Aβ(pE3–42) is abundant in AD brain and has a high aggregation propensity, stability and cellular toxicity. The aim o...

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Main Authors: Wittnam, Jessica L., Portelius, Erik, Zetterberg, Henrik, Gustavsson, Mikael K., Schilling, Stephan, Koch, Birgit, Demuth, Hans-Ulrich, Blennow, Kaj, Wirths, Oliver, Bayer, Thomas A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318696/
https://ncbi.nlm.nih.gov/pubmed/22267726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308601
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