Alternative Pathways for Production of Beta-Amyloid Peptides of Alzheimer’s Disease

af Hook, Vivian, Schechter, Israel, Demuth, Hans-Ulrich, Hook, Gregory
Udgivet 2008

Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy

af Dammers, Christina, Gremer, Lothar, Neudecker, Philipp, Demuth, Hans-Ulrich, Schwarten, Melanie, Willbold, Dieter
Udgivet i PLoS One (2015)

N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity

af Kehlen, Astrid, Haegele, Monique, Böhme, Livia, Cynis, Holger, Hoffmann, Torsten, Demuth, Hans-Ulrich
Udgivet i Biosci Rep (2017)

Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

af Wirths, Oliver, Breyhan, Henning, Cynis, Holger, Schilling, Stephan, Demuth, Hans-Ulrich, Bayer, Thomas A.
Udgivet 2009

Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Ph...

af Jawhar, Sadim, Wirths, Oliver, Schilling, Stephan, Graubner, Sigrid, Demuth, Hans-Ulrich, Bayer, Thomas A.
Udgivet 2011

Structure of glutaminyl cyclase from Drosophila melanogaster in space group I4

af Kolenko, Petr, Koch, Birgit, Rahfeld, Jens-Ulrich, Schilling, Stephan, Demuth, Hans-Ulrich, Stubbs, Milton T.
Udgivet 2013

Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study

af Frost, Jeffrey L., Liu, Bin, Kleinschmidt, Martin, Schilling, Stephan, Demuth, Hans-Ulrich, Lemere, Cynthia A.
Udgivet 2012

Natural Products from Microalgae with Potential against Alzheimer’s Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors

af Hielscher-Michael, Stephanie, Griehl, Carola, Buchholz, Mirko, Demuth, Hans-Ulrich, Arnold, Norbert, Wessjohann, Ludger A.
Udgivet i Mar Drugs (2016)

PyroGlu-Aβ and Glutaminyl Cyclase are Co-Localized with Aβ in Secretory Vesicles and Undergo Activity-Dependent Secretion

af Cynis, Holger, Funkelstein, Lydiane, Toneff, Thomas, Mosier, Charles, Ziegler, Michael, Koch, Britta, Demuth, Hans-Ulrich, Hook, Vivian
Udgivet 2014

Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway

af Kehlen Astrid, Meyer Antje, Menge Katja, Zeitschel Ulrike, Niestroj André J, Engel Claudia, Schulz Ingo, Roßner Steffen, Demuth Hans-Ulrich
Udgivet 2011-07-01

Pathological Hallmarks, Clinical Parallels, and Value for Drug Testing in Alzheimer's Disease of the APP[V717I] London Transgenic Mouse Model

af Tanghe, An, Termont, Annelies, Merchiers, Pascal, Schilling, Stephan, Demuth, Hans-Ulrich, Scrocchi, Louise, Van Leuven, Fred, Griffioen, Gerard, Van Dooren, Tom
Udgivet 2010

Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway

af Schulz, Ingo, Engel, Claudia, Niestroj, André J, Zeitschel, Ulrike, Menge, Katja, Kehlen, Astrid, Meyer, Antje, Roßner, Steffen, Demuth, Hans-Ulrich
Udgivet 2011

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

af Engel, Michael, Hoffmann, Torsten, Wagner, Leona, Wermann, Michael, Heiser, Ulrich, Kiefersauer, Reiner, Huber, Robert, Bode, Wolfram, Demuth, Hans-Ulrich, Brandstetter, Hans
Udgivet 2003

Glutaminyl Cyclases as Novel Targets for the Treatment of Septic Arthritis

af Hellvard, Annelie, Maresz, Katarzyna, Schilling, Stephan, Graubner, Sigrid, Heiser, Ulrich, Jonsson, Roland, Cynis, Holger, Demuth, Hans-Ulrich, Potempa, Jan, Mydel, Piotr
Udgivet 2013

Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice

af Cynis, Holger, Kehlen, Astrid, Haegele, Monique, Hoffmann, Torsten, Heiser, Ulrich, Fujii, Masato, Shibazaki, Yuichiro, Yoneyama, Hiroyuki, Schilling, Stephan, Demuth, Hans-Ulrich
Udgivet 2013

Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis

af Hellvard, Annelie, Zeitlmann, Lutz, Heiser, Ulrich, Kehlen, Astrid, Niestroj, André, Demuth, Hans-Ulrich, Koziel, Joanna, Delaleu, Nicolas, Jan Potempa, Mydel, Piotr
Udgivet i Sci Rep (2016)

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor

af Linnert, Miriam, Fritz, Claudia, Jäger, Christian, Schlenzig, Dagmar, Ramsbeck, Daniel, Kleinschmidt, Martin, Wermann, Michael, Demuth, Hans-Ulrich, Parthier, Christoph, Schilling, Stephan
Udgivet i Int J Mol Sci (2021)

Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor

af Parthier, Christoph, Kleinschmidt, Martin, Neumann, Piotr, Rudolph, Rainer, Manhart, Susanne, Schlenzig, Dagmar, Fanghänel, Jörg, Rahfeld, Jens-Ulrich, Demuth, Hans-Ulrich, Stubbs, Milton T.
Udgivet 2007

Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol

af Dammers, Christina, Gremer, Lothar, Reiß, Kerstin, Klein, Antonia N., Neudecker, Philipp, Hartmann, Rudolf, Sun, Na, Demuth, Hans-Ulrich, Schwarten, Melanie, Willbold, Dieter
Udgivet i PLoS One (2015)

Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy

af Piechotta, Anke, Parthier, Christoph, Kleinschmidt, Martin, Gnoth, Kathrin, Pillot, Thierry, Lues, Inge, Demuth, Hans-Ulrich, Schilling, Stephan, Rahfeld, Jens-Ulrich, Stubbs, Milton T.
Udgivet i J Biol Chem (2017)