Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

It is well established that only a fraction of Aβ peptides in the brain of Alzheimer’s disease (AD) patients start with N-terminal aspartate (Aβ(1D)) which is generated by proteolytic processing of amyloid precursor protein (APP) by BACE. N-terminally truncated and pyroglutamate modified Aβ starting...

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Bibliographic Details
Main Authors: Wirths, Oliver, Breyhan, Henning, Cynis, Holger, Schilling, Stephan, Demuth, Hans-Ulrich, Bayer, Thomas A.
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2009
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737116/
https://ncbi.nlm.nih.gov/pubmed/19547991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-009-0557-5
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