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Synergistic Effect on Neurodegeneration by N-Truncated Aβ(4−42) and Pyroglutamate Aβ(3−42) in a Mouse Model of Alzheimer's Disease
The N-terminally truncated pyroglutamate Aβ(3−42) (Aβ(pE3−42)) and Aβ(4−42) peptides are known to be highly abundant in the brain of Alzheimer's disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity in comparison to full-length Aβ, suggesting that these amyloid peptid...
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| Publicat a: | Front Aging Neurosci |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Frontiers Media S.A.
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5852075/ https://ncbi.nlm.nih.gov/pubmed/29568268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00064 |
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