Synergistic Effect on Neurodegeneration by N-Truncated Aβ(4−42) and Pyroglutamate Aβ(3−42) in a Mouse Model of Alzheimer's Disease

The N-terminally truncated pyroglutamate Aβ(3−42) (Aβ(pE3−42)) and Aβ(4−42) peptides are known to be highly abundant in the brain of Alzheimer's disease (AD) patients. Both peptides show enhanced aggregation and neurotoxicity in comparison to full-length Aβ, suggesting that these amyloid peptid...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Lopez-Noguerola, Jose S., Giessen, Nicolai M. E., Ueberück, Maximilian, Meißner, Julius N., Pelgrim, Charlotte E., Adams, Johnathan, Wirths, Oliver, Bouter, Yvonne, Bayer, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852075/
https://ncbi.nlm.nih.gov/pubmed/29568268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00064
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