Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X

Full-length Aβ1-42 and Aβ1-40, N-truncated pyroglutamate Aβ3-42 and Aβ4-42 are major variants in the Alzheimer brain. Aβ4-42 has not been considered as a therapeutic target yet. We demonstrate that the antibody NT4X and its Fab fragment reacting with both the free N-terminus of Aβ4-x and pyroglutama...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Antonios, Gregory, Borgers, Henning, Richard, Bernhard C., Brauß, Andreas, Meißner, Julius, Weggen, Sascha, Pena, Vladimir, Pillot, Thierry, Davies, Sarah L., Bakrania, Preeti, Matthews, David, Brownlees, Janet, Bouter, Yvonne, Bayer, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667289/
https://ncbi.nlm.nih.gov/pubmed/26626428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17338
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