N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

BACKGROUND: The amyloid hypothesis in Alzheimer disease (AD) considers amyloid β peptide (Aβ) deposition causative in triggering down-stream events like neurofibrillary tangles, cell loss, vascular damage and memory decline. In the past years N-truncated Aβ peptides especially N-truncated pyroglutam...

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Autors principals: Antonios, Gregory, Saiepour, Nasrin, Bouter, Yvonne, Richard, Bernhard C, Paetau, Anders, Verkkoniemi-Ahola, Auli, Lannfelt, Lars, Ingelsson, Martin, Kovacs, Gabor G, Pillot, Thierry, Wirths, Oliver, Bayer, Thomas A
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893517/
https://ncbi.nlm.nih.gov/pubmed/24252153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-56
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