Abundance of Aβ(5-x) like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer’s disease

BACKGROUND: According to the modified amyloid hypothesis the main event in the pathogenesis of Alzheimer’s disease (AD) is the deposition of neurotoxic amyloid β-peptide (Aβ) within neurons. Additionally to full-length peptides, a great diversity of N-truncated Aβ variants is derived from the larger...

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Main Authors: Guzmán, Erika Avendaño, Bouter, Yvonne, Richard, Bernhard C, Lannfelt, Lars, Ingelsson, Martin, Paetau, Anders, Verkkoniemi-Ahola, Auli, Wirths, Oliver, Bayer, Thomas A
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975588/
https://ncbi.nlm.nih.gov/pubmed/24694184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-13
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