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N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity
CX3CL1 (fractalkine) is a unique member of the CX3C chemokine family and mediates both adhesion and cell migration in inflammatory processes. Frequently, the activity of chemokines depends on a modified N-terminus as described for the N-terminus of CCL2 modified to a pGlu- (pyroglutamate) residue by...
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| 發表在: | Biosci Rep |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Portland Press Ltd.
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5634468/ https://ncbi.nlm.nih.gov/pubmed/28739588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20170712 |
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