Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice

Pyroglutamate-modified Aβ (AβpE3–42) peptides are gaining considerable attention as potential key players in the pathology of Alzheimer disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Overexpressing AβpE3–42 induced a severe neuron loss...

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Detalhes bibliográficos
Main Authors: Jawhar, Sadim, Wirths, Oliver, Schilling, Stephan, Graubner, Sigrid, Demuth, Hans-Ulrich, Bayer, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039372/
https://ncbi.nlm.nih.gov/pubmed/21148560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.185819
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