Glutaminyl Cyclase Knock-out Mice Exhibit Slight Hypothyroidism but No Hypogonadism: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT

Glutaminyl cyclases (QCs) catalyze the formation of pyroglutamate (pGlu) residues at the N terminus of peptides and proteins. Hypothalamic pGlu hormones, such as thyrotropin-releasing hormone and gonadotropin-releasing hormone are essential for regulation of metabolism and fertility in the hypothala...

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Auteurs principaux: Schilling, Stephan, Kohlmann, Stephanie, Bäuscher, Christoph, Sedlmeier, Reinhard, Koch, Birgit, Eichentopf, Rico, Becker, Andreas, Cynis, Holger, Hoffmann, Torsten, Berg, Sabine, Freyse, Ernst-Joachim, von Hörsten, Stephan, Rossner, Steffen, Graubner, Sigrid, Demuth, Hans-Ulrich
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Neurobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077621/
https://ncbi.nlm.nih.gov/pubmed/21330373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229385
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