The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

The membrane-bound glycoprotein dipeptidyl peptidase IV (DP IV, CD26) is a unique multifunctional protein, acting as receptor, binding and proteolytic molecule. We have determined the sequence and 1.8 Å crystal structure of native DP IV prepared from porcine kidney. The crystal structure reveals a 2...

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Autori principali: Engel, Michael, Hoffmann, Torsten, Wagner, Leona, Wermann, Michael, Heiser, Ulrich, Kiefersauer, Reiner, Huber, Robert, Bode, Wolfram, Demuth, Hans-Ulrich, Brandstetter, Hans
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC154298/
https://ncbi.nlm.nih.gov/pubmed/12690074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0230620100
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