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PyroGlu-Aβ and Glutaminyl Cyclase are Co-Localized with Aβ in Secretory Vesicles and Undergo Activity-Dependent Secretion
BACKGROUND AND AIMS: N-truncated pGlu-Aβ(3-40/42) peptides are key components that promote Aβ peptide accumulation, leading to neurodegeneration and memory loss in Alzheimer’s disease. Because Aβ deposition in brain occurs in an activity-dependent manner, it is important to define the subcellular or...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4141002/ https://ncbi.nlm.nih.gov/pubmed/24943989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000358430 |
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