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PyroGlu-Aβ and Glutaminyl Cyclase are Co-Localized with Aβ in Secretory Vesicles and Undergo Activity-Dependent Secretion

BACKGROUND AND AIMS: N-truncated pGlu-Aβ(3-40/42) peptides are key components that promote Aβ peptide accumulation, leading to neurodegeneration and memory loss in Alzheimer’s disease. Because Aβ deposition in brain occurs in an activity-dependent manner, it is important to define the subcellular or...

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Autori principali: Cynis, Holger, Funkelstein, Lydiane, Toneff, Thomas, Mosier, Charles, Ziegler, Michael, Koch, Britta, Demuth, Hans-Ulrich, Hook, Vivian
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141002/
https://ncbi.nlm.nih.gov/pubmed/24943989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000358430
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