Pharmacogenetic Features of Inhibitors to Cathepsin B that Improve Memory Deficit and Reduce Beta-Amyloid Related to Alzheimer’s Disease

Por Hook, Vivian, Hook, Gregory, Kindy, Mark
Publicado no Biol Chem (2010)

The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer’s disease animal models by inhibiting cathepsin B, but not BACE1, β-secreta...

Por Hook, Gregory, Hook, Vivian, Kindy, Mark
Publicado no J Alzheimers Dis (2011)

Alternative Pathways for Production of Beta-Amyloid Peptides of Alzheimer’s Disease

Por Hook, Vivian, Schechter, Israel, Demuth, Hans-Ulrich, Hook, Gregory
Publicado em 2008

Brain Pyroglutamate Amyloid-Beta is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer’s Disease Therapeutic

Por Hook, Gregory, Yu, Jin, Toneff, Thomas, Kindy, Mark, Hook, Vivian
Publicado em 2014

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate

Por Hook, Gregory, Jacobsen, J. Steven, Grabstein, Kenneth, Kindy, Mark, Hook, Vivian
Publicado no Front Neurol (2015)

GENETIC CATHEPSIN B DEFICIENCY REDUCES β-AMYLOID IN TRANSGENIC MICE EXPRESSING HUMAN WILD-TYPE AMYLOID PRECURSOR PROTEIN

Por Hook, Vivian Y. H., Kindy, Mark, Reinheckel, Thomas, Peters, Christoph, Hook, Gregory
Publicado em 2009

Cysteine Cathepsins in the Secretory Vesicle Produce Active Peptides: Cathepsin L Generates Peptide Neurotransmitters and Cathepsin B Produces Beta-Amyloid of Alzheimer’s Disease

Por Hook, Vivian, Funkelstein, Lydiane, Wegrzyn, Jill, Bark, Steven, Kindy, Mark, Hook, Gregory
Publicado em 2011

The Cysteine Protease Cathepsin B Is a Key Drug Target and Cysteine Protease Inhibitors Are Potential Therapeutics for Traumatic Brain Injury

Por Hook, Gregory R., Yu, Jin, Sipes, Nancy, Pierschbacher, Michael D., Hook, Vivian, Kindy, Mark S.
Publicado em 2014

Deletion of the Cathepsin B Gene Improves Memory Deficits in a Transgenic Alzheimer’s Disease Mouse Model Expressing AβPP Containing the Wild-Type β-Secretase Site Sequence

Por Kindy, Mark S., Yu, Jin, Zhu, Hong, El-Amouri, Salim S., Hook, Vivian, Hook, Gregory R.
Publicado no J Alzheimers Dis (2012)