Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy

Alzheimer disease is associated with deposition of the amyloidogenic peptide Aβ in the brain. Passive immunization using Aβ-specific antibodies has been demonstrated to reduce amyloid deposition both in vitro and in vivo. Because N-terminally truncated pyroglutamate (pE)-modified Aβ species (Aβ(pE3)...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Piechotta, Anke, Parthier, Christoph, Kleinschmidt, Martin, Gnoth, Kathrin, Pillot, Thierry, Lues, Inge, Demuth, Hans-Ulrich, Schilling, Stephan, Rahfeld, Jens-Ulrich, Stubbs, Milton T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535044/
https://ncbi.nlm.nih.gov/pubmed/28623233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.777839
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