An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice

Pyroglutamate-3 amyloid-beta (pGlu-3 Aβ) is an N-terminally truncated Aβ isoform likely playing a decisive role in Alzheimer's disease (AD) pathogenesis. Here, we describe a prophylactic passive immunization study in APPswe/PS1ΔE9 mice using a novel pGlu-3 Aβ IgG1 monoclonal antibody (mAb), 07/...

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Publicat a:Neurobiol Aging
Autors principals: Frost, Jeffrey L., Liu, Bin, Rahfeld, Jens-Ulrich, Kleinschmidt, Martin, O'Nuallain, Brian, Le, Kevin X., Lues, Inge, Caldarone, Barbara J., Schilling, Stephan, Demuth, Hans-Ulrich, Lemere, Cynthia A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4641825/
https://ncbi.nlm.nih.gov/pubmed/26453001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2015.08.021
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