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Mass spectrometric characterization of brain amyloid beta isoform signatures in familial and sporadic Alzheimer’s disease

A proposed key event in the pathogenesis of Alzheimer’s disease (AD) is the formation of neurotoxic amyloid β (Aβ) oligomers and amyloid plaques in specific brain regions that are affected by the disease. The main plaque component is the 42 amino acid isoform of Aβ (Aβ1-42), which is thought to init...

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Bibliografiska uppgifter
Huvudupphovsmän: Portelius, Erik, Bogdanovic, Nenad, Gustavsson, Mikael K., Volkmann, Inga, Brinkmalm, Gunnar, Zetterberg, Henrik, Winblad, Bengt, Blennow, Kaj
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568930/
https://ncbi.nlm.nih.gov/pubmed/20419305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-010-0690-1
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