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APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment

INTRODUCTION: Alzheimer’s disease brains are characterized by extracellular plaques containing the aggregated amyloid β(42) (Aβ(42)) peptide and intraneuronal tangles containing hyperphosphorylated tau. Aβ(42) is produced by sequential processing of the amyloid precursor protein (APP) by β-secretase...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Sjödin, Simon, Andersson, Kerstin K. A., Mercken, Marc, Zetterberg, Henrik, Borghys, Herman, Blennow, Kaj, Portelius, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687145/
https://ncbi.nlm.nih.gov/pubmed/26689589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-015-0160-z
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