APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment

INTRODUCTION: Alzheimer’s disease brains are characterized by extracellular plaques containing the aggregated amyloid β(42) (Aβ(42)) peptide and intraneuronal tangles containing hyperphosphorylated tau. Aβ(42) is produced by sequential processing of the amyloid precursor protein (APP) by β-secretase...

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Bibliografiske detaljer
Udgivet i:Alzheimers Res Ther
Main Authors: Sjödin, Simon, Andersson, Kerstin K. A., Mercken, Marc, Zetterberg, Henrik, Borghys, Herman, Blennow, Kaj, Portelius, Erik
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687145/
https://ncbi.nlm.nih.gov/pubmed/26689589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-015-0160-z
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