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APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment
INTRODUCTION: Alzheimer’s disease brains are characterized by extracellular plaques containing the aggregated amyloid β(42) (Aβ(42)) peptide and intraneuronal tangles containing hyperphosphorylated tau. Aβ(42) is produced by sequential processing of the amyloid precursor protein (APP) by β-secretase...
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| 出版年: | Alzheimers Res Ther |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687145/ https://ncbi.nlm.nih.gov/pubmed/26689589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-015-0160-z |
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