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APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment
INTRODUCTION: Alzheimer’s disease brains are characterized by extracellular plaques containing the aggregated amyloid β(42) (Aβ(42)) peptide and intraneuronal tangles containing hyperphosphorylated tau. Aβ(42) is produced by sequential processing of the amyloid precursor protein (APP) by β-secretase...
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| Pubblicato in: | Alzheimers Res Ther |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687145/ https://ncbi.nlm.nih.gov/pubmed/26689589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-015-0160-z |
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