BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease

The BACE1 gene encodes the beta-site APP-cleaving enzyme 1 and has been associated with Alzheimer's disease (AD). BACE1 is the most important β-secretase responsible for the generation of Alzheimer-associated amyloid β-proteins (Aβ) and may play a role in the amyloidogenic process in AD. We hyp...

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Detaylı Bibliyografya
Asıl Yazarlar: Sjölander, Annica, Zetterberg, Henrik, Andreasson, Ulf, Minthon, Lennart, Blennow, Kaj
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2010
Konular:
Short Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2949866/
https://ncbi.nlm.nih.gov/pubmed/20849576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-37
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