CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer’s disease

BACKGROUND: The presynaptic protein neuregulin1 (NRG1) is cleaved by beta-site APP cleaving enzyme 1 (BACE1) in a similar way as amyloid precursor protein (APP) NRG1 can activate post-synaptic receptor tyrosine-protein kinase erbB4 (ErbB4) and was linked to schizophrenia. The NRG1/ErbB4 complex is n...

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Detalhes bibliográficos
Publicado no:Alzheimers Res Ther
Main Authors: Mouton-Liger, François, Dumurgier, Julien, Cognat, Emmanuel, Hourregue, Claire, Zetterberg, Henrik, Vanderstichele, Hugo, Vanmechelen, Eugeen, Bouaziz-Amar, Elodie, Blennow, Kaj, Hugon, Jacques, Paquet, Claire
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7372801/
https://ncbi.nlm.nih.gov/pubmed/32690068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-00655-w
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