In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

Soluble amyloid-β (Aβ) peptide converts to structures with high β-sheet content in Alzheimer's disease (AD). Soluble Aβ is released by neurons into the brain interstitial fluid (ISF), in which it can convert into toxic aggregates. Because assessment of ISF Aβ levels may provide unique insights...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Cirrito, John R., May, Patrick C., O'Dell, Mark A., Taylor, Jennie W., Parsadanian, Maia, Cramer, Jeffrey W., Audia, James E., Nissen, Jeffrey S., Bales, Kelly R., Paul, Steven M., DeMattos, Ronald B., Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740389/
https://ncbi.nlm.nih.gov/pubmed/14523085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-26-08844.2003
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