In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

Soluble amyloid-β (Aβ) peptide converts to structures with high β-sheet content in Alzheimer's disease (AD). Soluble Aβ is released by neurons into the brain interstitial fluid (ISF), in which it can convert into toxic aggregates. Because assessment of ISF Aβ levels may provide unique insights...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Cirrito, John R., May, Patrick C., O'Dell, Mark A., Taylor, Jennie W., Parsadanian, Maia, Cramer, Jeffrey W., Audia, James E., Nissen, Jeffrey S., Bales, Kelly R., Paul, Steven M., DeMattos, Ronald B., Holtzman, David M.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2003
Sujets:
Cellular/Molecular
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740389/
https://ncbi.nlm.nih.gov/pubmed/14523085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-26-08844.2003
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