TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor that recognizes changes in the lipid microenvironment, which may occur during amyloid β (Aβ) accumulation and neuronal degeneration in Alzheimer’s disease (AD). Rare TREM2 variants that affect TREM2 function lead to an...

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Bibliografische gegevens
Gepubliceerd in:J Exp Med
Hoofdauteurs: Wang, Yaming, Ulland, Tyler K., Ulrich, Jason D., Song, Wilbur, Tzaferis, John A., Hole, Justin T., Yuan, Peng, Mahan, Thomas E., Shi, Yang, Gilfillan, Susan, Cella, Marina, Grutzendler, Jaime, DeMattos, Ronald B., Cirrito, John R., Holtzman, David M., Colonna, Marco
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2016
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854736/
https://ncbi.nlm.nih.gov/pubmed/27091843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151948
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