TREM2 maintains microglial metabolic fitness in Alzheimer’s disease

Elevated risk of developing Alzheimer’s disease (AD) is associated with hypomorphic variants of TREM2, a surface receptor required for microglial responses to neurodegeneration, including proliferation, survival, clustering and phagocytosis. How TREM2 promotes such diverse responses is unknown. Here...

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Udgivet i:Cell
Main Authors: Ulland, Tyler K., Song, Wilbur M, Huang, Stanley Ching-Cheng, Ulrich, Jason D., Sergushichev, Alexey, Beatty, Wandy L., Loboda, Alexander A., Zhou, Yingyue, Cairns, Nigel J., Kambal, Amal, Loginicheva, Ekaterina, Gilfillan, Susan, Cella, Marina, Virgin, Herbert W., Unanue, Emil R., Wang, Yaming, Artyomov, Maxim N., Holtzman, David M., Colonna, Marco
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573224/
https://ncbi.nlm.nih.gov/pubmed/28802038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.023
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