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TREM2 maintains microglial metabolic fitness in Alzheimer’s disease
Elevated risk of developing Alzheimer’s disease (AD) is associated with hypomorphic variants of TREM2, a surface receptor required for microglial responses to neurodegeneration, including proliferation, survival, clustering and phagocytosis. How TREM2 promotes such diverse responses is unknown. Here...
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| Pubblicato in: | Cell |
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| Autori principali: | , , , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5573224/ https://ncbi.nlm.nih.gov/pubmed/28802038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.023 |
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