TREM2 maintains microglial metabolic fitness in Alzheimer’s disease

Elevated risk of developing Alzheimer’s disease (AD) is associated with hypomorphic variants of TREM2, a surface receptor required for microglial responses to neurodegeneration, including proliferation, survival, clustering and phagocytosis. How TREM2 promotes such diverse responses is unknown. Here...

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Pubblicato in:Cell
Autori principali: Ulland, Tyler K., Song, Wilbur M, Huang, Stanley Ching-Cheng, Ulrich, Jason D., Sergushichev, Alexey, Beatty, Wandy L., Loboda, Alexander A., Zhou, Yingyue, Cairns, Nigel J., Kambal, Amal, Loginicheva, Ekaterina, Gilfillan, Susan, Cella, Marina, Virgin, Herbert W., Unanue, Emil R., Wang, Yaming, Artyomov, Maxim N., Holtzman, David M., Colonna, Marco
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573224/
https://ncbi.nlm.nih.gov/pubmed/28802038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.023
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